The album includes many of the shows recurring and special guests, from comedians like Aziz Ansari, Sarah Silverman, Kevin Kline, Bill Hader, Zack Galifianakis and Fred Armisen, to musical guests Cyndi Lauper and Carly Simon. The album also includes an additional five "Bob's Buskers" cover versions of songs from the show performed by St. Vincent, The National, Lapsley, and Stephin Merritt of Magnetic Fields.